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Increasing Diversity of Human Thyroperoxidase Generated by Alternative Splicing

1 Feb 2003

Abstract excerpt

The human thyroperoxidase (hTPO) gene is composed of 17 exons. The longest complete cDNA sequence determined so far contains a full-length hTPO (TPO1) encoding a 933-amino acid polypeptide. Several mRNA species encoding for hTPO isoforms are present in normal thyroid tissues, including TPO2 with exon 10 deleted and TPOzanelli with exon 16 deleted. In the present study, we established the existence of two new...

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PMID: 12454013
DOI: 10.1074/jbc.m209513200

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