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Article

Covariation of GC content and the silent site substitution rate in rodents: implications for methodology and for the evolution of isochores.

Gene - 30 Dec 2000

Hurst L D, Williams E J

Abstract excerpt

Many attempts to test selectionist and neutralist models employ estimates of synonymous (Ks) and non-synonymous (Ka) substitution rates of orthologous genes. For example, a stronger Ka-Ks correlation than expected under neutrality has been argued to indicate a role for selection and the absence of a Ks-GC4 correlation has been argued to be inconsistent with neutral models for isochore evolution. However, both of...

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PMID: 11164042
DOI: 10.1016/s0378-1119(00)00489-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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