Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The causes of synonymous rate variation in the rodent genome. Can substitution rates be used to estimate the sex bias in mutation rate?

Genetics - 1 Jun 1999

Smith N G, Hurst L D

Abstract excerpt

Miyata et al. have suggested that the male-to-female mutation rate ratio (alpha) can be estimated by comparing the neutral substitution rates of X-linked (X), Y-linked (Y), and autosomal (A) genes. Rodent silent site X/A comparisons provide very different estimates from X/Y comparisons. We examine three explanations for this discrepancy: (1) statistical biases and artifacts, (2) nonneutral evolution, and (3)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Composition
Share to Chromosomes
Share to Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Imprinting

Share to Rodentia

Share to Statistics as Topic

Share to X Chromosome

Share to Y Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 10353908
DOI: 10.1093/genetics/152.2.661
PMCID: PMC1460631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The causes of synonymous rate variation in the rodent genome. Can substitution rates be used to estimate the sex bias in mutation rate?PMID 10353908Read ↗

Evidence for a selectively favourable reduction in the mutation rate of the X chromosome.Semantic proximity Read ↗

Strong and weak male mutation bias at different sites in the primate genomes: insights from the human-chimpanzee comparison.Semantic proximity Read ↗

Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA.Semantic proximity Read ↗

Genic mutation rates in mammals: local similarity, chromosomal heterogeneity, and X-versus-autosome disparity.Semantic proximity Read ↗

Mammalian gene evolution: nucleotide sequence divergence between mouse and rat.Semantic proximity Read ↗

Local similarity in evolutionary rates extends over whole chromosomes in human-rodent and mouse-rat comparisons: implications for understanding the mechanistic basis of the male mutation bias.Semantic proximity Read ↗

The effect of tandem substitutions on the correlation between synonymous and nonsynonymous rates in rodents.Semantic proximity Read ↗

Unexpectedly similar rates of nucleotide substitution found in male and female hominids.Semantic proximity Read ↗

Potential problems in estimating the male-to-female mutation rate ratio from DNA sequence data.Semantic proximity Read ↗

Male-driven evolution of DNA sequences.Semantic proximity Read ↗

A novel method distinguishes between mutation rates and fixation biases in patterns of single-nucleotide substitution.Semantic proximity Read ↗

Covariation of GC content and the silent site substitution rate in rodents: implications for methodology and for the evolution of isochores.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.