Article
Mutations in the yeast Nhp6 protein can differentially affect its in vivo functions.
Biochemical and biophysical research communications - 9 Feb 2001
Kruppa M, Kolodrubetz D
Abstract excerpt
Nhp6A and Nhp6B from S. cerevisiae are required for viability at 38 degrees C because they are involved in transcription of SNR6 by RNA polymerase III. Nhp6A also represses transcription of NHP6B by RNA polymerase II. Nhp6 belongs to the HMG1 family, defined by an 80 amino acid DNA binding domain, which includes six highly conserved residues. These amino acids were mutated in Nhp6A and their affects on Nhp6...
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