Article
Ral promotes anchorage-independent growth of a human fibrosarcoma, HT1080.
Biochemical and biophysical research communications - 26 Jan 2001
Yamazaki Y, Kaziro Y, Koide H
Abstract excerpt
Ral has been shown to act downstream of Ras oncoprotein. However, the role of Ral in Ras-induced cellular transformation has not been fully understood. To test the involvement of Ral in Ras-induced anchorage-independent growth, we ectopically expressed Ral mutants in HT1080 cells, whose ability to grow in the absence of anchorage depends on the oncogenic mutation of N-ras. Expression of an activated mutant of Ral...
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