Article
CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer.
Oncogene - 6 Aug 1998
Wicking C, Simms L A, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B, Wainwright B
Abstract excerpt
The Cdx2 gene is one of three murine homologues of the Drosophila homeobox gene caudal. Mice heterozygous for a null mutation in Cdx2 exhibit a variable phenotype including tail abnormalities, stunted growth and a homeotic shift of vertebrae. Most strikingly, however, 90% of heterozygous mice wer...
Topics
- Adenocarcinoma
- Aged
- Aged, 80 and over
- Alleles
- Animals
- CDX2 Transcription Factor
- Colorectal Neoplasms
- Drosophila
- Drosophila Proteins
- Female
- Homeodomain Proteins
- Humans
- Male
- Mice
- Mutation
- Polymorphism, Genetic