Article
Platelet glycoprotein Ibalpha Kozak polymorphism is associated with an increased risk of ischemic stroke.
Blood - 1 Jul 2001
Baker R I, Eikelboom J, Lofthouse E, Staples N, Afshar-Kharghan V, López J A, Shen Y, Berndt M C, Hankey G
Abstract excerpt
Platelets are pivotal to the process of arterial thrombosis resulting in ischemic stroke. Occlusive thrombosis is initiated by the interaction of von Willebrand factor (vWf) and platelet glycoprotein (GP) Ibalpha. Three polymorphisms have been described in GP Ibalpha (Kozak T/C polymorphism, variable number of tandem repeats [VNTR], and the human platelet antigen 2a [HPA-2a] [Thr] or HPA-2b [Met] at position...
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