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Article

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta.

Development (Cambridge, England) - 1 Apr 2002

Coffinier Catherine, Gresh Lionel, Fiette Laurence, Tronche François, Schütz Günther, Babinet Charles, Pontoglio Marco, Yaniv Moshe, Barra Jacqueline

Abstract excerpt

The inactivation of the Hnf1beta gene identified an essential role in epithelial differentiation of the visceral endoderm and resulted in early embryonic death. In the present study, we have specifically inactivated this gene in hepatocytes and bile duct cells using the Cre/loxP system. Mutant an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11934849
DOI: 10.1242/dev.129.8.1829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11934849-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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