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Identification of a Novel Two-Component Regulatory System That Acts in Global Regulation of Virulence Factors of<i>Staphylococcus aureus</i>

15 Feb 2001

Abstract excerpt

We have previously demonstrated that the presence of oxygen is necessary for the production of toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus aureus in vitro. To investigate the mechanism by which oxygen might regulate toxin production, we identified homologs in S. aureus of the Bacillus subtilis resDE genes. The two-component regulatory system encoded by resDE, ResD-ResE, has been implicated in the...

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PMID: 11157922
DOI: 10.1128/jb.183.4.1113-1123.2001

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