Article
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.
Molecular and cellular biology - 1 Sept 1999
Koochekpour S, Jeffers M, Wang P H, Gong C, Taylor G A, Roessler L M, Stearman R, Vasselli J R, Stetler-Stevenson W G, Kaelin W G, Linehan W M, Klausner R D, Gnarra J R, Vande Woude G F
Abstract excerpt
Loss of function in the von Hippel-Lindau (VHL) tumor suppressor gene occurs in familial and most sporadic renal cell carcinomas (RCCs). VHL has been linked to the regulation of cell cycle cessation (G(0)) and to control of expression of various mRNAs such as for vascular endothelial growth factor. RCC cells express the Met receptor tyrosine kinase, and Met mediates invasion and branching morphogenesis in many...
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