Article
Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin.
Molecular biology of the cell - 1 Feb 2009
Harten Sarah K, Shukla Deepa, Barod Ravi, Hergovich Alexander, Balda Maria S, Matter Karl, Esteban Miguel A, Maxwell Patrick H
Abstract excerpt
Epithelial-to-mesenchymal transitions (EMT) are important in renal development, fibrosis, and cancer. Loss of function of the tumor suppressor VHL leads to many features of EMT, and it has been hypothesized that the pivotal mediator is down-regulation of the adherens junction (AJ) protein E-cadherin. Here we show that VHL loss-of-function also has striking effects on the expression of the tight junction (TJ)...
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