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Article

Induction of a secreted protein by the myxoid liposarcoma oncogene

27 Apr 1999

Abstract excerpt

The TLS-CHOP oncoprotein, found in the majority of human myxoid liposarcomas, consists of a fusion between the transcription factor CHOP/GADD153 and the N terminus of an RNA-binding protein TLS/FUS. Clinical correlation and in vitro transformation assays indicate that the N terminus of TLS plays an important role in oncogenesis by TLS-CHOP. Until now, however, the only activity attributed to the oncoprotein is...

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PMID: 10220412
DOI: 10.1073/pnas.96.9.5025

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Induction of a secreted protein by the myxoid liposarcoma oncogenePMID 10220412Read ↗

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