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Article

mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.

Genes, chromosomes & cancer - 1 May 2011

Spitzer Jessica I, Ugras Stacy, Runge Simon, Decarolis Penelope, Antonescu Christina, Tuschl Tom, Singer Samuel

Abstract excerpt

Translocations or mutations of FUS, EWSR1, and TAF15 (FET) result in distinct genetic diseases. N-terminal translocations of any FET protein to a series of transcription factors yields chimeric proteins that contribute to sarcomagenesis, whereas mutations in the conserved COOH-terminal domain of wild-type FUS were recently shown to cause familial amyotrophic lateral sclerosis. We thus investigated whether the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21344536
DOI: 10.1002/gcc.20858
PMCID: PMC3056538

Genes

FUS
EWSR1
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.PMID 21344536Read ↗

Expression of the FUS-CHOP Fusion Protein in Primary Mesenchymal Progenitor Cells Gives Rise to a Model of Myxoid LiposarcomaSemantic proximity Read ↗

Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant FunctionsSemantic proximity Read ↗

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Liposarcoma initiated by FUS/TLS-CHOP: the FUS/TLS domain plays a critical role in the pathogenesis of liposarcoma.Semantic proximity Read ↗

Expression Patterns of the Human Sarcoma-Associated GenesFUSandEWSand the Genomic Structure ofFUSSemantic proximity Read ↗

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