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Article

The ribosomal binding and peptidyl-tRNA hydrolysis functions of Escherichia coli release factor 2 are linked through residue 246.

RNA (New York, N.Y.) - 1 Dec 2000

Wilson D N, Guévremont D, Tate W P

Abstract excerpt

Replacing a cassette of 31 residues from Escherichia coli release factor 1 with the equivalent residues in release factor 2 gave a protein active in codon-specific binding to the ribosome but inactive in peptidyl-tRNA hydrolysis. Such a phenotype is also found unexpectedly with release factor 2 when expressed at high concentration in bacteria. Substituting threonine with the release factor 1 equivalent serine at...

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Share to Hydrolysis
Share to Peptide Chain Termination, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Termination Factors

Share to RNA, Transfer, Amino Acyl

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Share to Structure-Activity Relationship

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Source

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Identifiers

PMID: 11142371
DOI: 10.1017/s135583820000131x
PMCID: PMC1370041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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