Article
Role of macrophage scavenger receptors in hepatic granuloma formation in mice.
The American journal of pathology - 1 Mar 1999
Hagiwara S I, Takeya M, Suzuki H, Kodama T, van der Laan L J, Kraal G, Kitamura N, Takahashi K
Abstract excerpt
In mice homozygous for the gene mutation for type I and type II macrophage scavenger receptors (MSR-A), MSR-A-/-, the formation of hepatic granulomas caused by a single intravenous injection of heat-killed Corynebacterium parvum was delayed significantly for 10 days after injection, compared with granuloma formation in wild-type (MSR-A+/+) mice. In the early stage of granuloma formation, numbers of macrophages...
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