Article
EGFR protein overexpression and mutation in areca quid-associated oral cavity squamous cell carcinoma in Taiwan.
Head & neck - 1 Aug 2009
Huang Shiang-Fu, Chuang Wen-Yu, Chen I-How, Liao Chun-Ta, Wang Hung-Ming, Hsieh Ling-Ling
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR)-targeted therapy has been extensively assessed in human cancer treatment. We appraised the possible role of tyrosine kinase inhibitors (TKIs) in areca quid (AQ)-associated oral cavity squamous cell carcinomas (OSCCs) by examining EGFR protein overexpression and its tyrosine kinase domain mutations. METHODS: EGFR overexpression was evaluated by...
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