Article
Covalently linked heme in cytochrome p4504a fatty acid hydroxylases.
The Journal of biological chemistry - 6 Apr 2001
Hoch U, Ortiz De Montellano P R
Abstract excerpt
Three independent experimental methods, liquid chromatography, denaturing gel electrophoresis with heme staining, and mass spectrometry, establish that the CYP4A class of enzymes has a covalently bound heme group even though the heme is not cross-linked to the protein in other P450 enzymes. Covalent binding has been demonstrated for CYP4A1, -4A2, -4A3, -4A8, and -4A11 heterologously expressed in Escherichia coli....
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