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Article

A non-linear optimization procedure to estimate distances and instantaneous substitution rate matrices under the GTR model.

Bioinformatics (Oxford, England) - 15 Mar 2006

Catanzaro Daniele, Pesenti Raffaele, Milinkovitch Michel C

Abstract excerpt

MOTIVATION: The general-time-reversible (GTR) model is one of the most popular models of nucleotide substitution because it constitutes a good trade-off between mathematical tractability and biological reality. However, when it is applied for inferring evolutionary distances and/or instantaneous rate matrices, the GTR model seems more prone to inapplicability than more restrictive time-reversible models. Although...

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PMID: 16397009
DOI: 10.1093/bioinformatics/btk001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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