Article
Integrin alpha3beta1 engagement disrupts intercellular adhesion.
Experimental cell research - 15 Jan 2001
Kawano K, Kantak S S, Murai M, Yao C C, Kramer R H
Abstract excerpt
During tissue morphogenesis and tumor invasion, epithelial cells must undergo intercellular rearrangement in which cells are repositioned with respect to one another and the surrounding mesenchymal extracellular matrix. Using three-dimensional aggregates of squamous epithelial cells, we show that such intercellular rearrangements can be triggered by activation of beta1 integrins after their ligation with...
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