Article
Characterization of integrin and anchorage dependence in mammary epithelial cells following c-erbB2-induced epithelial-mesenchymal transition.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2006
Jenndahl Lachmi E, Taylor-Papadimitriou Joyce, Baeckstrom Dan
Abstract excerpt
Signalling from the proto-oncogene c-erbB2 in mammary epithelial cells has earlier been shown to result in epithelial-mesenchymal transition (EMT) giving rise to fibroblast-like cells, and acquisition of anchorage-independent growth (AIG) usually determined by growth capacity in soft agar. In this study, we have analysed AIG associated with c-erbB2-induced EMT in a human mammary epithelial cell line....
Topics
- Breast Neoplasms
- Cell Communication
- Cell Proliferation
- Epithelial Cells
- Extracellular Matrix
- Female
- Fibroblasts
- Humans
- Integrins
- Mammary Glands, Human
- Mesoderm
- Phenotype
- Proto-Oncogene Mas
- Receptor, ErbB-2
- Receptors, Fibronectin
- Signal Transduction
- Up-Regulation