Article
X chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications.
Human molecular genetics - 1 Jan 2001
Sudbrak R, Wieczorek G, Nuber U A, Mann W, Kirchner R, Erdogan F, Brown C J, Wöhrle D, Sterk P, Kalscheuer V M, Berger W, Lehrach H, Ropers H H
Abstract excerpt
Mutant alleles are frequently characterized by low expression levels. Therefore, cDNA array-based gene expression profiling may be a promising strategy for identifying gene defects underlying monogenic disorders. To study the potential of this approach, we have generated an X chromosome-specific microarray carrying 2423 cloned cDNA fragments, which represent up to 1317 different X-chromosomal genes. As a prelude...
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