Article
The systematic functional characterisation of Xq28 genes prioritises candidate disease genes.
BMC genomics - 17 Feb 2006
Kolb-Kokocinski Anja, Mehrle Alexander, Bechtel Stephanie, Simpson Jeremy C, Kioschis Petra, Wiemann Stefan, Wellenreuther Ruth, Poustka Annemarie
Abstract excerpt
BACKGROUND: Well known for its gene density and the large number of mapped diseases, the human sub-chromosomal region Xq28 has long been a focus of genome research. Over 40 of approximately 300 X-linked diseases map to this region, and systematic mapping, transcript identification, and mutation analysis has led to the identification of causative genes for 26 of these diseases, leaving another 17 diseases mapped...
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