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Article

Structural and numerical variation of FLT3/ITD in pediatric AML

27 Feb 2008

Abstract excerpt

FLT3 internal tandem duplication (FLT3/ITD) is a common somatic mutation in acute myeloid leukemia (AML) with significant variation in the position, length, and number of duplications of the FLT3 gene. We evaluated these physical characteristics in FLT3/ITD-positive patients who were treated on CCG-2941/2961 and correlated them with clinical outcome. Fiftynine of 77 FLT3/ITD-positive patients (77%) had a single...

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PMID: 18305215
DOI: 10.1182/blood-2008-01-117770

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