Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Individual variability in the zinc inducibility of metallothionein-IIA mRNA in human lymphocytes.

Journal of toxicology and environmental health. Part A - 15 Dec 2000

Wu M T, Demple B, Bennett R A, Christiani D C, Fan R, Hu H

Abstract excerpt

The metallothionein-III gene (MT-IIA) is a major member of the human MT gene family. Metallothioneins (MTs) are low-molecular-weight, cysteine-rich proteins that bind and detoxify heavy metals. At least two different MT-IIA polymorphisms have been identified in humans, one or both of which may affect susceptibility to metal toxicity. The purpose of this study was to investigate whether these different genotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Enzyme Induction

Share to HeLa Cells

Share to Lymphocytes

Share to Metallothionein

Source

Identifiers

PMID: 11127411
DOI: 10.1080/00984100050194081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Individual variability in the zinc inducibility of metallothionein-IIA mRNA in human lymphocytes.PMID 11127411Read ↗

Potential effect on cellular response to cadmium of a single-nucleotide A --> G polymorphism in the promoter of the human gene for metallothionein IIA.Semantic proximity Read ↗

The effects of metallothionein 2A polymorphism on placental cadmium accumulation: Is metallothionein a modifiying factor in transfer of micronutrients to the fetus?Semantic proximity Read ↗

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.Semantic proximity Read ↗

The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter.Semantic proximity Read ↗

Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene.Semantic proximity Read ↗

Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I.Semantic proximity Read ↗

Functional analyses of the human metallothionein-IG gene. In vitro and in vivo studies.Semantic proximity Read ↗

Human Metallothionein Expression under Normal and Pathological Conditions: Mechanisms of Gene Regulation Based on In silico Promoter AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.