Functional analyses of the human metallothionein-IG gene. In vitro and in vivo studies.

doi:10.1074/jbc.270.42.25194

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Article

Functional analyses of the human metallothionein-IG gene. In vitro and in vivo studies.

The Journal of biological chemistry - 20 Oct 1995

Samson S L, Paramchuk W J, Shworak N W, Gedamu L

Abstract excerpt

We have analyzed the human (h) metallothionein (MT)-IG proximal promoter region (-174 to +5) using a TATA box mutation (TATCA) and four trinucleotide mutants of the proximal MREa. Transient transfection of HepG2 cells was complemented by in vitro transcription with rat liver nuclear extracts. In both systems, mutations of the TATA box and conserved core of metal responsive element (MRE)a were detrimental to...

Topics

Animals
Base Sequence
DNA-Binding Proteins
Deoxyribonuclease I
Genes, Regulator
Humans
Male
Metallothionein
Molecular Sequence Data
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Sprague-Dawley

TATA Box

TATA-Box Binding Protein

Transcription Factors

Transcription, Genetic

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7559655
DOI: 10.1074/jbc.270.42.25194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7559655-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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