Article
Potential effect on cellular response to cadmium of a single-nucleotide A --> G polymorphism in the promoter of the human gene for metallothionein IIA.
Human genetics - 1 Nov 2006
Kita Kayoko, Miura Nobuhiko, Yoshida Minoru, Yamazaki Kentaro, Ohkubo Takayoshi, Imai Yutaka, Naganuma Akira
Abstract excerpt
Most people generally ingest cadmium in their food. Cadmium that has accumulated in tissues induces the synthesis of metallothioneins (MTs) which are metal-binding proteins that bind tightly to cadmium to inhibit its renal toxicity. Individuals whose ability to induce the synthesis of MTs is low seem likely to be particularly susceptible to the toxic effects of cadmium. In this study, we analyzed the polymorphism...
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