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Article

T lymphocytes promote the development of bone marrow-derived APC in the central nervous system.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2001

Subramanian S, Bourdette D N, Corless C, Vandenbark A A, Offner H, Jones R E

Abstract excerpt

Certain cells within the CNS, microglial cells and perivascular macrophages, develop from hemopoietic myelomonocytic lineage progenitors in the bone marrow (BM). Such BM-derived cells function as CNS APC during the development of T cell-mediated paralytic inflammation in diseases such as experimental autoimmune encephalomyelitis and multiple sclerosis. We used a novel, interspecies, rat-into-mouse T cell and/or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11123314
DOI: 10.4049/jimmunol.166.1.370

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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