The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina.

doi:10.4049/jimmunol.172.11.6587

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Article

The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2004

Gregerson Dale S, Sam Thien N, McPherson Scott W

Abstract excerpt

Although several observations show local T cell recognition of retinal Ag, there has been no direct demonstration that the APC were retinal derived, rather than recruited. In this study, CD45(+) cells isolated from immunologically quiescent murine retina were tested in vitro for functional evidence of Ag presentation to naive and Ag-experienced CD4 T cells specific for beta-galactosidase. Because CD45(+) cells...

Topics

Animals
Antigen Presentation
Dendritic Cells
Leukocyte Common Antigens
Lipopolysaccharides
Mice
Mice, Inbred C57BL
Microglia
Phenotype
Retina
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 15153473
DOI: 10.4049/jimmunol.172.11.6587

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