Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IgA immunodeficiency leads to inadequate Th cell priming and increased susceptibility to influenza virus infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2001

Arulanandam B P, Raeder R H, Nedrud J G, Bucher D J, Le J, Metzger D W

Abstract excerpt

IgA is considered to be the principal Ab involved in defense against pathogens in the mucosal compartment. Using mice with a targeted disruption in IgA gene expression (IgA(-/-) mice), we have examined the precise role of IgA in protective anti-influenza responses after intranasal vaccination. IgA(-/-) mice immunized intranasally with soluble hemagglutinin (hemagglutinin subtype 1) and neuraminidase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Intranasal
Share to HN Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to IgA Deficiency

Share to Immunoglobulin A

Share to Influenza Vaccines

Share to Lymphoproliferative Disorders

Share to Orthomyxoviridae Infections

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 11123296
DOI: 10.4049/jimmunol.166.1.226

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IgA immunodeficiency leads to inadequate Th cell priming and increased susceptibility to influenza virus infection.PMID 11123296Read ↗

Mechanisms of heterosubtypic immunity to lethal influenza A virus infection in fully immunocompetent, T cell-depleted, β2-microglobulin-deficient, and J chain-deficient miceSemantic proximity Read ↗

Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.Semantic proximity Read ↗

Modified Live Attenuated Influenza B Virus Vaccines and Sex-driven Differences on Humoral Immune Responses in the DBA/2J Mouse ModelSemantic proximity Read ↗

Consequences of suboptimal priming are apparent for low-avidity T-cell responses.Semantic proximity Read ↗

Mucosal Correlates of Protection after Influenza Viral Challenge of Vaccinated and Unvaccinated Healthy VolunteersSemantic proximity Read ↗

Attenuated <i>Bordetella pertussis</i> Protects against Highly Pathogenic Influenza A Viruses by Dampening the Cytokine StormSemantic proximity Read ↗

Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections.Semantic proximity Read ↗

Protection and compensation in the influenza virus-specific CD8+ T cell response.Semantic proximity Read ↗

Poliovirus Sabin type 1 neutralization epitopes recognized by immunoglobulin A monoclonal antibodies.Semantic proximity Read ↗

Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.Semantic proximity Read ↗

Expression of IgA Proteases by Haemophilus influenzae in the Respiratory Tract of Adults With Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

Aberrant IgG2 antibody response to Neisseria meningitidis polysaccharide A after vaccination in frequently infected compared to healthy IgA-deficient individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.