Article
Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide.
American journal of medical genetics - 4 Dec 2000
Bondy B, Kuznik J, Baghai T, Schüle C, Zwanzger P, Minov C, de Jonge S, Rupprecht R, Meyer H, Engel R R, Eisenmenger W, Ackenheil M
Abstract excerpt
Serotonergic dysfunction has been implicated in the pathophysiology of affective disorders and suicidality. Especially the density of the 5-HT2A receptor was claimed as being increased in suicidality, proposed as an adaptive upregulation due to reduced serotonergic transmission. Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major...
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