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Article

Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction

18 Dec 2000

Abstract excerpt

Somatic hypermutation specifically modifies rearranged immunoglobulin (Ig) genes in germinal center (GC) B cells. However, the bcl-6 gene can also acquire somatic mutations during the GC reaction, indicating that certain non-Ig genes can be targeted by the somatic hypermutation machinery. The CD95 gene, implicated in negative selection of B lymphocytes in GCs, is specifically expressed by GC B cells and was...

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PMID: 11120779
DOI: 10.1084/jem.192.12.1833

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Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center ReactionPMID 11120779Read ↗

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