Article
Prostacyclin analogues differentially inhibit growth of distal and proximal human pulmonary artery smooth muscle cells.
Circulation - 19 Dec 2000
Wharton J, Davie N, Upton P D, Yacoub M H, Polak J M, Morrell N W
Abstract excerpt
BACKGROUND: Prostacyclin has proved to be a beneficial treatment for patients with severe pulmonary hypertension. We postulated that the response may reflect, at least in part, inhibition of pulmonary artery smooth muscle cell (PASMC) growth. METHODS AND RESULTS: Human PASMCs were derived from distal (<1-mm external diameter, n=8) and proximal (>8-mm external diameter, n=12) pulmonary arteries obtained at...
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