Article
Adrenomedullin expression and growth inhibitory effects in distinct pulmonary artery smooth muscle cell subpopulations.
American journal of respiratory cell and molecular biology - 1 Feb 2001
Upton P D, Wharton J, Coppock H, Davie N, Yang X, Yacoub M H, Ghatei M A, Polak J M, Bloom S R, Smith D M, Morrell N W
Abstract excerpt
The vasodilator peptide adrenomedullin is elevated in patients with pulmonary hypertension and has been implicated in the inhibition of vascular remodeling. We questioned whether adrenomedullin is released by human pulmonary artery smooth muscle cells (PASMCs) and inhibits PASMC growth and release of endothelin, a known smooth muscle cell mitogen. The majority of PASMCs isolated from proximal pulmonary arteries...
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