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Article

Structures of thermolabile mutants of human glutathione transferase P1-1.

Journal of molecular biology - 15 Sept 2000

Rossjohn J, McKinstry W J, Oakley A J, Parker M W, Stenberg G, Mannervik B, Dragani B, Cocco R, Aceto A

Abstract excerpt

An N-capping box motif (Ser/Thr-Xaa-Xaa-Asp) is strictly conserved at the beginning of helix alpha6 in the core of virtually all glutathione transferases (GST) and GST-related proteins. It has been demonstrated that this local motif is important in determining the alpha-helical propensity of the isolated alpha6-peptide and plays a crucial role in the folding and stability of GSTs. Its removal by site-directed...

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Source

Identifiers

PMID: 10970734
DOI: 10.1006/jmbi.2000.4054

Genes

GSTP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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