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Article

trans-acting inhibition of genomic RNA dimerization by Rous sarcoma virus matrix mutants.

Journal of virology - 1 Jan 2001

Garbitt R A, Albert J A, Kessler M D, Parent L J

Abstract excerpt

The genomic RNA of retroviruses exists within the virion as a noncovalently linked dimer. Previously, we identified a mutant of the viral matrix (MA) protein of Rous sarcoma virus that disrupts viral RNA dimerization. This mutant, Myr1E, is modified at the N terminus of MA by the addition of 10 amino acids from the Src protein, resulting in the production of particles containing monomeric RNA. Dimerization is...

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Identifiers

PMID: 11119596
DOI: 10.1128/JVI.75.1.260-268.2001
PMCID: PMC113920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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