Article
Conditional infectivity of a human immunodeficiency virus matrix domain deletion mutant.
Journal of virology - 1 Dec 1993
Wang C T, Zhang Y, McDermott J, Barklis E
Abstract excerpt
We constructed a human immunodeficiency virus (HIV) matrix (MA) deletion mutant by deletion of about 80% of the HIV type 1 Gag MA domain but retaining myristylation and proteolytic processing signals. The effects of this deletion matrix (dl.MA) mutant on HIV particle assembly, processing, and infectivity were analyzed. Surprisingly, the dl.MA mutant still could assemble and process virus particles, had a...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- Gene Products, gag
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Protein Processing, Post-Translational