Article
Mutator natural Escherichia coli isolates have an unusual virulence phenotype.
Infection and immunity - 1 Jan 2001
Picard B, Duriez P, Gouriou S, Matic I, Denamur E, Taddei F
Abstract excerpt
A small percentage of natural Escherichia coli isolates (both commensal and pathogenic) have a mutator phenotype related to defects in methyl-directed mismatch repair (MR) genes. We investigated whether there was a direct link between the mutator phenotype and virulence by (i) studying the relationships between mutation rate and virulence in a mouse model of extraintestinal virulence for 88 commensal and...
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