Article
Mutator phenotype confers advantage in Escherichia coli chronic urinary tract infection pathogenesis.
FEMS immunology and medical microbiology - 1 Jun 2005
Labat Francoise, Pradillon Olivier, Garry Louis, Peuchmaur Michel, Fantin Bruno, Denamur Erick
Abstract excerpt
It has been suggested that mutator phenotype could be associated with an increase in virulence, but to date experimental evidences are lacking. Epidemiological studies have revealed that urinary tract infection isolates encompass the highest proportion of mutator strains within the Escherichia coli species. Using the uropathogenic strain CFT073 and its mutS- mutator mutant, we show that the mutator strain is...
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