Article
Mutations of the second extracellular loop of the human lutropin receptor emphasize the importance of receptor activation and de-emphasize the importance of receptor phosphorylation in agonist-induced internalization.
The Journal of biological chemistry - 16 Mar 2001
Li S, Liu X, Min L, Ascoli M
Abstract excerpt
Alanine scanning mutagenesis of the second extracellular loop of the human lutropin receptor (hLHR) showed that mutation of most of the residues present in this region either enhance or impair the internalization of agonist. A more complete analysis of four mutants, two that enhanced internalization (F515A and T521A) and two that impaired internalization (S512A and V519A), showed that the two mutants that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.