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Article

Rad50 Is Dispensable for the Maintenance and Viability of Postmitotic Tissues

11 Nov 2008

Abstract excerpt

The majority of spontaneous chromosome breakage occurs during the process of DNA replication. Homologous recombination is the primary mechanism of repair of such damage, which probably accounts for the fact that it is essential for genome integrity and viability in mammalian cells. The Mre11 complex plays diverse roles in the maintenance of genomic integrity, influencing homologous recombination, checkpoint...

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Identifiers

PMID: 19001091
DOI: 10.1128/mcb.01525-08

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