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Article

Apical membrane antigen 1 plays a central role in erythrocyte invasion by <i>Plasmodium</i> species

1 Nov 2000

Abstract excerpt

Apical membrane antigen 1 (AMA1) is an asexual blood-stage protein expressed in the invasive merozoite form of Plasmodia species, which are the causative agent of malaria. We have complemented the function of Plasmodium falciparum AMA1 (PfAMA1) with a divergent AMA1 transgene from Plasmodium chabaudi (PcAMA1). It was not possible to disrupt the PfAMA1 gene using 'knock-out' plasmids, although we demonstrate that...

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Identifiers

PMID: 11115107
DOI: 10.1046/j.1365-2958.2000.02175.x

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