Article
Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiency.
European journal of immunology - 1 Jan 2003
Lichtenauer-Kaligis Elgin G R, de Boer Tjitske, Verreck Frank A W, van Voorden Sjaak, Hoeve Marieke A, van de Vosse Esther, Ersoy Fugen, Tezcan Ilhan, van Dissel Jaap T, Sanal Ozden, Ottenhoff Tom H M
Abstract excerpt
Cell mediated immunity plays a critical role in human host defence against intracellular bacteria. In patients with unusual, severe infections caused by poorly pathogenic species of mycobacteria and salmonellae, genetic deficiencies have been identified in key genes in the type-1 cytokine pathway, especially in IFNGR1 and IL12RB1. Here, we analyzed 11 patients originating from Turkey and suffering from unusual...
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