A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1.

Abstract excerpt

Cytochrome c (Cc) binding to apoptosis protease activation factor-1 (Apaf-1) is a critical activation step in the execution phase of apoptosis. Here we report studies that help define the Cc:Apaf-1 binding surface. It is shown that a large number of Cc residues, including residues 7, 25, 39, 62-65, and 72, are involved in the Cc:Apaf-1 interaction. Mutation of residue 72 eliminated Cc activity whereas mutations...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Apoptotic Protease-Activating Factor 1