Article
Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells.
The American journal of pathology - 1 Dec 2000
LaMontagne K R, Moses M A, Wiederschain D, Mahajan S, Holden J, Ghazizadeh H, Frank D A, Arbiser J L
Abstract excerpt
Activated ras causes increased activity of several signal transduction systems, including the mitogen-activated protein kinase kinase (MAPKK) pathway and the phosphoinositol-3-kinase (PI-3-K) pathway. We have previously shown that the PI-3-K pathway plays a major role in regulation of ras-mediated tumor angiogenesis in angiosarcoma cells. However, the contribution of the MAPKK pathway to tumorigenesis and...
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