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Article

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

1 Dec 2000

Abstract excerpt

The chemokine stromal-derived factor-1 (SDF-1) controls many aspects of stem cell function. Details of its regulation and sites of production are currently unknown. We report that in the bone marrow, SDF-1 is produced mainly by immature osteoblasts and endothelial cells. Conditioning with DNA-damaging agents (ionizing irradiation, cyclophosphamide, and 5-fluorouracil) caused an increase in SDF-1 expression and in...

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PMID: 11104786
DOI: 10.1172/jci10329

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