Article
Dynamic associations of heterochromatin protein 1 with the nuclear envelope.
The EMBO journal - 1 Dec 2000
Kourmouli N, Theodoropoulos P A, Dialynas G, Bakou A, Politou A S, Cowell I G, Singh P B, Georgatos S D
Abstract excerpt
To study the dynamics of mammalian HP1 proteins we have microinjected recombinant forms of mHP1alpha, M31 and M32 into the cytoplasm of living cells. As could be expected from previous studies, the three fusion proteins were efficiently transported into the nucleus and targeted specific chromatin areas. However, before incorporation into these areas the exogenous proteins accumulated in a peripheral zone and...
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