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Article

No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease.

International journal of molecular medicine - 1 Nov 2000

Papassotiropoulos A, Bagli M, Becker K, Jessen F, Maier W, Rao M L, Ludwig M, Heun R

Abstract excerpt

The cleavage of the amyloid precursor protein (APP) into amyloidogenic components (Abeta) is a central event in the pathogenesis of Alzheimer's disease (AD). FE65 is a protein that is involved in APP metabolism and may facilitate the production of Abeta. Recently, an intronic polymorphism of the gene encoding FE65 (FE65) was associated with altered risk for the development of sporadic AD. In our sample of 102 AD...

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Identifiers

PMID: 11029529
DOI: 10.3892/ijmm.6.5.587

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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