Article
Substance P receptor expression in human skin keratinocytes and fibroblasts
28 Jun 2006
Abstract excerpt
BACKGROUND: There is increasing evidence that neuropeptides, especially substance P (SP), may be involved in the pathogenesis of cutaneous allergic inflammation (CAI). OBJECTIVES: To investigate expression of the SP receptor (neurokinin-1 receptor, NK-1R) in human epidermal keratinocytes and dermal fibroblasts and its potential influence in CAI. METHODS: HaCaT cells (a human epidermal keratinocyte cell line) and...
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