Article
Natural killer cells trigger differentiation of monocytes into dendritic cells.
Blood - 1 Oct 2007
Zhang Angela L, Colmenero Paula, Purath Ulrich, Teixeira de Matos Cristina, Hueber Wolfgang, Klareskog Lars, Tarner Ingo H, Engleman Edgar G, Söderström Kalle
Abstract excerpt
Circulating monocytes can differentiate into dendritic cells (moDCs), which are potent inducers of adaptive immune responses. Previous reports show that granulocyte macrophage-colony-stimulating factor (GM-CSF) and interleukin-4 induce monocyte differentiation into moDCs in vitro, but little is known about the physiological requirements that initiate moDC differentiation in vivo. Here we show that a unique...
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