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Article

Syncytial Mutations Do Not Impair the Specificity of Entry and Spread of a Glycoprotein D Receptor-Retargeted Herpes Simplex Virus.

Journal of virology - 15 Dec 2016

Okubo Yu, Uchida Hiroaki, Wakata Aika, Suzuki Takuma, Shibata Tomoko, Ikeda Hitomi, Yamaguchi Miki, Cohen Justus B, Glorioso Joseph C, Tagaya Mitsuo, Hamada Hirofumi, Tahara Hideaki

Abstract excerpt

Membrane fusion, which is the key process for both initial cell entry and subsequent lateral spread of herpes simplex virus (HSV), requires the four envelope glycoproteins gB, gD, gH, and gL. Syncytial mutations, predominantly mapped to the gB and gK genes, confer hyperfusogenicity on HSV and cause multinucleated giant cells, termed syncytia. Here we asked whether interaction of gD with a cognate entry receptor...

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Identifiers

PMID: 27707922
DOI: 10.1128/JVI.01456-16
PMCID: PMC5126368

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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